Label case studies
Cupramine and conditioners: read the combination warning before the dose
A product-history checklist for the reducing-agent warning in Seachem’s Cupramine directions.
Formulation evidence record
Seachem Cupramine
External parasite treatment (copper-amine) · US formulation
Shrimp
Amano, cherry, crystal and other freshwater shrimp.
Snails
Nerite, mystery, ramshorn and other aquarium snails.
Live plants
Rooted and floating live aquarium plants.
Marine invertebrates
Corals, anemones, starfish and marine crustaceans.
Biological filter
The nitrifying bacteria in your filter media.
Not addressed by the manufacturer for: scaleless fish. No statement was found, so no verdict is given — that is not a clearance.
Why FishyMag says this
The manufacturer's own wording, quoted rather than paraphrased, so you can judge it yourself.
Shrimp
Manufacturer advises againstSeachem instructs keepers to remove all invertebrates before treatment, describing them as extremely sensitive to copper.
Contains copper, with a source-linked caution associated with this group. This raises a flag—it is not the basis of the verdict above.
“Remove all invertebrates - these are extremely sensitive to copper and will not tolerate treatment with a copper-based medication.”
manufacturer page · seachem.com · checked August 16, 2026
Snails
Manufacturer advises againstSnails are invertebrates and fall under the same instruction to remove all invertebrates before treatment.
Contains copper, with a source-linked caution associated with this group. This raises a flag—it is not the basis of the verdict above.
“Remove all invertebrates - these are extremely sensitive to copper and will not tolerate treatment with a copper-based medication.”
manufacturer page · seachem.com · checked August 16, 2026
Live plants
No evidence foundSeachem does not address live plants in its Cupramine documentation. No statement was found either way, so this stays unknown rather than being assumed safe.
No manufacturer statement was found for this group. That is not the same as a clearance — treat it as unconfirmed and ask the manufacturer before dosing.
Marine invertebrates
Manufacturer advises againstCovered by the same blanket instruction to remove all invertebrates.
Contains copper, with a source-linked caution associated with this group. This raises a flag—it is not the basis of the verdict above.
“Remove all invertebrates - these are extremely sensitive to copper and will not tolerate treatment with a copper-based medication.”
manufacturer page · seachem.com · checked August 16, 2026
Biological filter
No evidence foundSeachem does not address effects on biological filtration in its Cupramine documentation.
No manufacturer statement was found for this group. That is not the same as a clearance — treat it as unconfirmed and ask the manufacturer before dosing.
Check the evidence boundary
What this record can—and cannot—answer
Bottle identity
US formulation · label revision: not recorded · version: not recorded.
Match the label and concentration on your bottle before using a dose ratio.
Unresolved groups
Live plants, Scaleless fish, Biological filter
Missing evidence is not a compatibility finding.
Product combinations
No specific interaction warning is recorded here. This is not a complete interaction review or permission to combine treatments.
Evidence age
Formulation record checked August 16, 2026. Source dates can differ within the record. A dated check is not a guarantee that the label has stayed unchanged.
Product details
- Manufacturer states it treats
- Ich, Velvet, External protozoan parasites
- Chemical filtration
- Remove chemical filtration during treatment
- Ingredients as stated
- Copper-amine complex. Dosed to 0.5 mg/L in saltwater and 0.25 mg/L in freshwater, held for 14 days.
- Active ingredients
- Copper
manufacturer page · seachem.com · checked August 16, 2026
Record last checked August 16, 2026 · confidence high
Check against your tank
Change what is in your tank to see how the answer moves.
The biological filter is included in every non-empty tank check, alongside your selected groups.
External parasite treatment (copper-amine) · US formulation
The manufacturer advises against using this with your tank.
At least one selected group is named in a warning. Read the exact instruction and ask the manufacturer to clarify your setup before dosing.
This answers for the assumed selection above, not a tank you have described. Adjust it if it is not yours.
- ShrimpManufacturer advises against
Seachem instructs keepers to remove all invertebrates before treatment, describing them as extremely sensitive to copper.
- SnailsManufacturer advises against
Snails are invertebrates and fall under the same instruction to remove all invertebrates before treatment.
- Live plantsNo evidence found
Seachem does not address live plants in its Cupramine documentation. No statement was found either way, so this stays unknown rather than being assumed safe.
- Biological filterNo evidence found
Seachem does not address effects on biological filtration in its Cupramine documentation.
See the manufacturer’s exact wording and sources for Seachem Cupramine →
No evidence found means no manufacturer statement was found — not that the product is safe. FishyMag does not diagnose disease or recommend treatments.
Other treatments
Seachem ParaGuardFritz Aquatics Algae Clean OutFritz Aquatics Mardel CoppersafeAPI Liquid Super Ick CureSeachem MetroPlexSeachem PolyGuardFritz Aquatics PraziCleanseAPI General CureFritz Aquatics ParaCleanseSeachem KanaPlexSeachem NeoPlexSeachem FocusSeachem StressGuardAPI MELAFIXFritz Aquatics Expel-PFritz Aquatics MaracynSeachem SulfaPlexAPI PIMAFIXFritz Aquatics Maracyn TwoFritz Aquatics Maracyn OxyFritz Aquatics FixIckFritz Aquatics Expel-FFritz Aquatics MetroCleanse
Understand the label in context
Label case studies
StressGuard: a livestock statement is not permission to combine products
Why the invertebrate answer and copper-medication restriction address different questions.
Next steps
Does this record match your bottle?Compare the name, market and label details. Download unresolved identity questions.Resolve an unanswered question about Seachem CupramineDownload the evidence and a manufacturer enquiry with your bottle details and livestock groups.Keep a treatment recordRecord what was actually used and when. Save on this device or export for a support conversation.How much Seachem Cupramine for my tank?Scales the label ratio to your real water volume, with the manufacturer wording beside the answer.Check against my tankSee how Seachem Cupramine and every other treatment compare against what you actually keep.Compare with another treatmentPut Seachem Cupramine beside up to three alternatives, group by group.Work out your real water volumeDose against the water your tank holds, not the number on the box.
FishyMag reports what manufacturers say, quoted and linked. It does not diagnose illness or recommend a treatment, and it never infers that a product is safe from the absence of a warning — where no statement exists, it says so.
Formulations change. Always read the label on the bottle in your hand, and contact the manufacturer if your tank contains anything valuable or unusual.