Formulation evidence record

Seachem NeoPlex

Bacterial infection treatment · US formulation

Shrimp

Amano, cherry, crystal and other freshwater shrimp.

Conflicting

Snails

Nerite, mystery, ramshorn and other aquarium snails.

Conflicting

Live plants

Rooted and floating live aquarium plants.

Caution

Biological filter

The nitrifying bacteria in your filter media.

Compatible

Not addressed by the manufacturer for: scaleless fish, marine invertebrates. No statement was found, so no verdict is given — that is not a clearance.

Why FishyMag says this

The manufacturer's own wording, quoted rather than paraphrased, so you can judge it yourself.

Shrimp

Sources disagree

Seachem contradicts itself on this product. One passage says NeoPlex is well tolerated by invertebrates with delicate species possibly stressed; another instructs keepers to remove all invertebrates as extremely sensitive to medication. Both appear on the same page. Seachem also suggests medicating via Focus-bound food instead of the water column, which reads as an acknowledgement of the risk.

Contains neomycin sulfate, with a source-linked caution associated with this group. This raises a flag—it is not the basis of the verdict above.

“It is well tolerated by invertebrates, although delicate species may be stressed.”

manufacturer page · seachem.com · checked August 16, 2026

“Remove all invertebrates - these are extremely sensitive to medication.”

manufacturer page · seachem.com · checked August 16, 2026

Snails

Sources disagree

The same two contradictory statements cover snails. Until Seachem clarifies, treat the more restrictive instruction as the operative one.

Contains neomycin sulfate, with a source-linked caution associated with this group. This raises a flag—it is not the basis of the verdict above.

“It is well tolerated by invertebrates, although delicate species may be stressed.”

manufacturer page · seachem.com · checked August 16, 2026

“Remove all invertebrates - these are extremely sensitive to medication.”

manufacturer page · seachem.com · checked August 16, 2026

Live plants

Caution

Rather than clearing plants, Seachem steers planted-tank keepers toward medicating through Focus-bound frozen food to keep medication out of the water column.

“Using a medicated food mix will prevent damage to delicate plants or invertebrates from medication.”

manufacturer page · seachem.com · checked August 16, 2026

Biological filter

Manufacturer states compatible

Seachem lists NeoPlex as having minimal impact on the biological filter.

“Minimal impact on bio-filter”

manufacturer page · seachem.com · checked August 16, 2026

Product details

Manufacturer states it treats: Bacterial infections, Internal and external infections
Chemical filtration: Remove chemical filtration during treatment
Ingredients as stated: Neomycin sulfate (43%).
Active ingredients: Neomycin sulfate

manufacturer page · seachem.com · checked August 16, 2026

Record last checked August 16, 2026 · confidence high

Check against your tank

Change what is in your tank to see how the answer moves.

1 Choose the treatment

Bacterial infection treatment · US formulation

2 Select everything in the tank

Assuming a common community tank. Change the selection, or save your tank so every page answers for it.

Sources disagree about your tank.

We found credible sources that contradict each other. Both are shown below so you can judge — when in doubt, follow the manufacturer.

This answers for the assumed selection above, not a tank you have described. Adjust it if it is not yours.

ShrimpSources disagree
Seachem contradicts itself on this product. One passage says NeoPlex is well tolerated by invertebrates with delicate species possibly stressed; another instructs keepers to remove all invertebrates as extremely sensitive to medication. Both appear on the same page. Seachem also suggests medicating via Focus-bound food instead of the water column, which reads as an acknowledgement of the risk.
SnailsSources disagree
The same two contradictory statements cover snails. Until Seachem clarifies, treat the more restrictive instruction as the operative one.
Live plantsCaution
Rather than clearing plants, Seachem steers planted-tank keepers toward medicating through Focus-bound frozen food to keep medication out of the water column.

See the manufacturer’s exact wording and sources for Seachem NeoPlex →

No evidence found means no manufacturer statement was found — not that the product is safe. FishyMag does not diagnose disease or recommend treatments.

Next steps

How much Seachem NeoPlex for my tank?Scales the label ratio to your real water volume, with the manufacturer wording beside the answer.Check against my tankSee how Seachem NeoPlex and every other treatment compare against what you actually keep.Compare with another treatmentPut Seachem NeoPlex beside up to three alternatives, group by group.Work out your real water volumeDose against the water your tank holds, not the number on the box.

FishyMag reports what manufacturers say, quoted and linked. It does not diagnose illness or recommend a treatment, and it never infers that a product is safe from the absence of a warning — where no statement exists, it says so.

Formulations change. Always read the label on the bottle in your hand, and contact the manufacturer if your tank contains anything valuable or unusual.